Kids' Kidneys Can Work Well in Adult Recipients
BOSTON—Transplantation of kidneys from child donors into adult recipients can achieve good outcomes, according to researchers.
Laurence J. Belin, MD, and colleagues at New York-Presbyterian/Weill Cornell Medical Center in New York reviewed 51 cases in adults received kidneys from donors younger than five years over a six-year period. One-year patient and graft survival were 97.8% and 94%, respectively, which was comparable to that of adult recipients of adult standard-criteria deceased donor kidneys at their institution, investigators reported at the 2012 American Transplant Congress.
The mean age of the recipients was 45.4 years and the mean donor age was 19.4 months. The mean graft size was 6.5 cm. Five graft losses occurred: two because of primary non-function in patients who received mate kidneys, one due to graft thrombosis that required a nephrectomy, one due to immune-mediated rejection at three years, and one because of parvoviral infection at three years. The acute rejection rate at one year was 4%.
The investigators concluded that transplant surgeons should be encouraged to use child donor kidneys, which frequently are discarded.