Possible reasons include malabsorption of immunosuppressive drugs and deposition of oxalate crystals in transplanted kidneys.
Rates of non-adherence to follow-up care and medication regimens also found to differ by race.
Some donors spend years on dialysis before being placed on the kidney transplant waiting list.
Each Hounsfield unit increase on CT is associated with a 7% decreased risk of death among waitlisted kidney transplant candidates.
Coronary artery disease before transplantation increases death risk by 77%, study finds.
An eGFR decline of at least 30% during the 6 to 24 months after kidney transplantation predicts a higher risk of graft loss.
In a study, viral infections occurred in 52.4% of patients with a BMI of 35 kg/m2 or higher compared with 37.1% of those with a lower BMI.
Patients discharged with home health or to a skilled nursing facility also were more likely to be readmitted.
At the end of a 22-year study period, the 1- and 3-year risk of graft loss did not differs significantly between black and white recipients.
Study reveals a 13% incidence of CIN in allograft recipients undergoing computed tomography or cardiac catheterization with contrast media.
A 30% decline in eGFR between 1 and 3 years post-transplant is associated with an increased risk of all-cause graft loss and patient death.
Study of renal transplant patients also shows that proton pump inhibitors are associated with increased arterial stiffness.
Recipients of diabetic donor kidneys—especially diabetic recipients—are at increased risk of graft loss and death.
Recipients of AKI kidneys have patient and graft survival rates similar to those of recipients of non-AKI kidneys.
Kidney recipients who lost the most weight prior to transplantation had a 25% decreased risk versus those with the most weight gain.
Recipients aged 65 years and older who receive kidneys from donors in the same age group have a higher risk of death and delayed graft function.
Death risk increased by 55% if patients are rehospitalized within 30 days of kidney transplantation.
Allograft function at one year post-transplant is more likely to be low if the donors are small.
Study finds a 60% increased likelihood of being hospitalized within 30 days of kidney transplant-related discharge.
Renal function improves over time in donors, declines with chronic kidney disease.
Reasons may include increasing prevalence of diabetes and obesity, economic disincentives, and transplant center oversight.
Systolic blood pressure of 160 mm Hg or higher raised death-censored graft loss risk twofold.
New findings could explain, at least in part, why live kidney donation has stagnated in the U.S.
Persistent need for dialysis at discharge increased the likelihood of readmission nearly threefold, study finds.
Recipients of kidneys from smokers are twice as likely to die as patients who get kidneys from nonsmokers.
From 2004 to 2010, the median fall in eGFR in the first year after donation grew significantly from 23.3 to 31.9 mL/min/1.73 m2.
Delayed graft function in patients aged 70 and older increased their death risk twofold.
The annual per-patient cost for kidney transplant recipients dropped from $33,040 in 2007 to $18,746 in 2011.
Cytomegalovirus viremia less likely with 200 rather than 100 days of valganciclovir after kidney transplantation.
Study characterizes cytomegalovirus infections in a large population of kidney transplant recipients.
In a study, vitamin D and calcium supplementation for one year made no difference in bone mineral density.
At-risk transplant recipients, however, have a lower risk of graft failure with prophylaxis than preemptive therapy.
Elderly patients who remain on dialysis are three times more likely to die than those who receive a deceased-donor kidney transplant.
BOSTON—Preemptive kidney transplantation may offer no survival advantage over kidney transplantation soon after dialysis initiation, according to new findings reported at the 2012 American Transplant Congress.
BOSTON—Researchers who examined renal outcomes in obese living kidney donors observed no increased incidence of hypertension, proteinuria, or renal dysfunction compared with non-obese donors at one year after nephrectomy.
BOSTON—Pediatric renal graft survival has improved over time, researchers reported at the 2012 American Transplant Congress.
BOSTON—Transplantation of kidneys from child donors into adult recipients can achieve good outcomes, according to researchers.
PHILADELPHIA—Delayed graft function (DGF) requiring more than one-time dialysis is associated with increased death risk, according to findings presented at the 2011 American Transplant Congress.
PHILADELPHIA—Higher urinary levels of two biomarkers on the first day following renal transplantation can predict poor graft function at one year, researchers reported at the 2011 American Transplant Congress.
PHILADELPHIA—Metabolic syndrome (MS) is present in 35%-40% of renal transplant recipients in the first five years post-transplant, new findings suggest.
PHILADELPHIA—Most renal transplant recipients (RTRs) fail to achieve recommended systolic blood pressure (SBP) levels despite being prescribed antihypertensive medications. Consequently, they may be at increased risk for cardiovascular disease (CVD), a study found.
PHILADELPHIA—Renal transplants recipients who receive a heavier kidney relative to their body weight have better long-term graft survival and early graft function, researchers reported.
PHILADELPHIA—Obese kidney donors are not at elevated risk for renal dysfunction long term, but they may experience an increase in risk factors for cardiovascular disease (CVD), according to researchers.
PHILADELPHIA—Abnormalities revealed by electrocardiography (ECG) may predict which patients undergoing evaluation for a renal transplant are at higher risk of death, a study found. These abnormalities include prolonged PR or QTc intervals.
PHILADELPHIA—Short-term treatment with high-dose erythropoietin (EPO)—which is known to have tissue protective effects—does not decrease the incidence or duration of delayed graft function (DGF) or primary non-function (PNF) in recipients of kidneys from non-heart-beating donors, but it is associated with significantly better and faster renal recovery, a study found.
PHILADELPHIA—Kidney transplant patients who undergo early corticosteroid withdrawal (ECSWD) have a significantly better survival free of cardiovascular (CV) events, according to investigators. The decrease in CV event does not become apparent until three or four years after transplantation.
SAN DIEGO—Donor kidney volume is a major determinant of allograft kidney function one year after renal transplantation, according to researchers.
SAN DIEGO—Non-black renal transplant patients infected with the hepatitis C virus (HCV) have better survival if they receive a kidney from a non-black rather than a black donor, data show.
SAN DIEGO—The duration of delayed graft function (DGF) influences mortality risk among renal transplant recipients surviving 90 days after transplantation, a study found.
SAN DIEGO—Deceased donor kidneys with acute kidney injury (AKI) offer excellent short term patient and graft survival, investigators reported here at the 2010 American Transplant Congress.
SAN DIEGO—Recipients of kidneys from expanded criteria donors (ECDs) with elevated terminal creatinine may be at higher risk for delayed graft function (DGF) and primary nonfunction (PNF).
SAN DIEGO—Low-dose fluconazole is safe and highly effective for antifungal prophylaxis after kidney transplantation, according to a study conducted by researchers at University of Utah Health Care in Salt Lake City.
SAN DIEGO—Hypomagnesemia in the first three months following renal transplantation may be a risk factor for the development of rapid new-onset type 2 diabetes (NODAT), according to researchers.
SAN DIEGO—Patients who undergo renal transplantation can experience significant weight gain in the first six months after the procedure, and the reason may not be related to changes in dietary intake.
Steroid-free maintenance immunosuppression with sirolimus and low-dose cyclosporine in renal transplant recipients is associated with "excellent" long-term patient and graft survival and a low acute rejection rate, according to researchers.
Shipping live-donor kidneys to transplant centers over long distances—even transcontinentally—does not adversely affect recipient outcomes, a recent experience involving four transplant centers suggests.
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NEPHROLOGY & UROLOGY NEWS
- Acute Kidney Injury (AKI)
- Chronic Kidney Disease (CKD)
- Contrast Nephropathy
- Cardiovascular Disease (CVD)
- Diabetic Nephropathy
- End-stage Renal Disease (ESRD)
- Lupus Nephritis
- Peritoneal Dialysis
- Secondary Hyperparathyroidism (SHPT)