Living Kidney Donation Declining in U.S.

Reasons may include increasing prevalence of diabetes and obesity, economic disincentives, and transplant center oversight.

Too Much Salt Raises Post-Transplant Hypertension Risk

Systolic blood pressure of 160 mm Hg or higher raised death-censored graft loss risk twofold.

Obesity Often Thwarts Living Kidney Donation

New findings could explain, at least in part, why live kidney donation has stagnated in the U.S.

Post-Transplant Dialysis Need Predicts Early Readmission

Persistent need for dialysis at discharge increased the likelihood of readmission nearly threefold, study finds.

Transplant Patient Death Risk Higher If Donors Are Smokers

Recipients of kidneys from smokers are twice as likely to die as patients who get kidneys from nonsmokers.

Living Kidney Donors Facing More Rapid Declines in Renal Function

From 2004 to 2010, the median fall in eGFR in the first year after donation grew significantly from 23.3 to 31.9 mL/min/1.73 m2.

DGF-Associated Mortality Higher in the Elderly

Delayed graft function in patients aged 70 and older increased their death risk twofold.

Immunosuppressive Drug Costs Decline, But Still Expensive

The annual per-patient cost for kidney transplant recipients dropped from $33,040 in 2007 to $18,746 in 2011.

Longer CMV Prophylaxis May Be Better

Cytomegalovirus viremia less likely with 200 rather than 100 days of valganciclovir after kidney transplantation.

Post-Transplant CMV Infection Hits GI Tract Hardest

Study characterizes cytomegalovirus infections in a large population of kidney transplant recipients.

Post-Transplant Bone Preservation Strategy Not Helpful

In a study, vitamin D and calcium supplementation for one year made no difference in bone mineral density.

Strategies Offer Similar Protection from CMV Disease

At-risk transplant recipients, however, have a lower risk of graft failure with prophylaxis than preemptive therapy.

Renal Transplants Improves Survival in the Elderly

Elderly patients who remain on dialysis are three times more likely to die than those who receive a deceased-donor kidney transplant.

Preemptive Transplants May Not Offer Survival Edge

BOSTON—Preemptive kidney transplantation may offer no survival advantage over kidney transplantation soon after dialysis initiation, according to new findings reported at the 2012 American Transplant Congress.

One-Year Outcomes Not Worse in Obese Kidney Donors

BOSTON—Researchers who examined renal outcomes in obese living kidney donors observed no increased incidence of hypertension, proteinuria, or renal dysfunction compared with non-obese donors at one year after nephrectomy.

Pediatric Renal Graft Survival Improving

BOSTON—Pediatric renal graft survival has improved over time, researchers reported at the 2012 American Transplant Congress.

Kids' Kidneys Can Work Well in Adult Recipients

BOSTON—Transplantation of kidneys from child donors into adult recipients can achieve good outcomes, according to researchers.

DGF Requiring More than One-Time Dialysis Raises Death Risk

PHILADELPHIA—Delayed graft function (DGF) requiring more than one-time dialysis is associated with increased death risk, according to findings presented at the 2011 American Transplant Congress.

Urine Biomarkers On First Day After Transplant Predict One-Year Outcomes

PHILADELPHIA—Higher urinary levels of two biomarkers on the first day following renal transplantation can predict poor graft function at one year, researchers reported at the 2011 American Transplant Congress.

Metabolic Syndrome Common After Renal Transplantation

PHILADELPHIA—Metabolic syndrome (MS) is present in 35%-40% of renal transplant recipients in the first five years post-transplant, new findings suggest.

Tx Patients Fail to Meet SBP Targets

PHILADELPHIA—Most renal transplant recipients (RTRs) fail to achieve recommended systolic blood pressure (SBP) levels despite being prescribed antihypertensive medications. Consequently, they may be at increased risk for cardiovascular disease (CVD), a study found.

Donor Kidney Weight Affects Transplant Outcomes

PHILADELPHIA—Renal transplants recipients who receive a heavier kidney relative to their body weight have better long-term graft survival and early graft function, researchers reported.

Obese Donors Not At Higher Renal Risk

Obese Donors Not At Higher Renal Risk

PHILADELPHIA—Obese kidney donors are not at elevated risk for renal dysfunction long term, but they may experience an increase in risk factors for cardiovascular disease (CVD), according to researchers.

ECG Findings May Identify Transplant Candidates at Higher Death Risk

ECG Findings May Identify Transplant Candidates at Higher Death Risk

PHILADELPHIA—Abnormalities revealed by electrocardiography (ECG) may predict which patients undergoing evaluation for a renal transplant are at higher risk of death, a study found. These abnormalities include prolonged PR or QTc intervals.

Delayed Graft Function Risk Not Lowered with High-Dose EPO

PHILADELPHIA—Short-term treatment with high-dose erythropoietin (EPO)—which is known to have tissue protective effects—does not decrease the incidence or duration of delayed graft function (DGF) or primary non-function (PNF) in recipients of kidneys from non-heart-beating donors, but it is associated with significantly better and faster renal recovery, a study found.

Early Steroid Withdrawal Cuts CV Event Rates in Transplant Recipients

Early Steroid Withdrawal Cuts CV Event Rates in Transplant Recipients

PHILADELPHIA—Kidney transplant patients who undergo early corticosteroid withdrawal (ECSWD) have a significantly better survival free of cardiovascular (CV) events, according to investigators. The decrease in CV event does not become apparent until three or four years after transplantation.

Donor Kidney Volume May Predict Post-Tx Function at One Year

SAN DIEGO—Donor kidney volume is a major determinant of allograft kidney function one year after renal transplantation, according to researchers.

Donor Race May Affect Survival of HCV-Infected Renal Transplant Patients

SAN DIEGO—Non-black renal transplant patients infected with the hepatitis C virus (HCV) have better survival if they receive a kidney from a non-black rather than a black donor, data show.

Mortality Linked to Duration of Delayed Graft Function

Mortality Linked to Duration of Delayed Graft Function

SAN DIEGO—The duration of delayed graft function (DGF) influences mortality risk among renal transplant recipients surviving 90 days after transplantation, a study found.

AKI Need Not Rule Out Kidney Donation

AKI Need Not Rule Out Kidney Donation

SAN DIEGO—Deceased donor kidneys with acute kidney injury (AKI) offer excellent short term patient and graft survival, investigators reported here at the 2010 American Transplant Congress.

ECD Factors Affecting Graft Outcomes Identified

ECD Factors Affecting Graft Outcomes Identified

SAN DIEGO—Recipients of kidneys from expanded criteria donors (ECDs) with elevated terminal creatinine may be at higher risk for delayed graft function (DGF) and primary nonfunction (PNF).

Low-Dose Fluconazole Prophylaxis After Renal Transplantation is Safe and Effective

Low-Dose Fluconazole Prophylaxis After Renal Transplantation is Safe and Effective

SAN DIEGO—Low-dose fluconazole is safe and highly effective for antifungal prophylaxis after kidney transplantation, according to a study conducted by researchers at University of Utah Health Care in Salt Lake City.

New-Onset Diabetes Linked to Post-Transplant Hypomagnesemia

SAN DIEGO—Hypomagnesemia in the first three months following renal transplantation may be a risk factor for the development of rapid new-onset type 2 diabetes (NODAT), according to researchers.

Post-Transplant Weight Gain May Be Unrelated to Dietary Intake

SAN DIEGO—Patients who undergo renal transplantation can experience significant weight gain in the first six months after the procedure, and the reason may not be related to changes in dietary intake.

Transplant Outcomes 'Excellent' with Steroid-Free Immunosuppression

Steroid-free maintenance immunosuppression with sirolimus and low-dose cyclosporine in renal transplant recipients is associated with "excellent" long-term patient and graft survival and a low acute rejection rate, according to researchers.

Live-Donor Kidneys Withstand Long-Distance Travel

Live-Donor Kidneys Withstand Long-Distance Travel

Shipping live-donor kidneys to transplant centers over long distances—even transcontinentally—does not adversely affect recipient outcomes, a recent experience involving four transplant centers suggests.

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