August 28, 2008
WASHINGTON, D.C.—Impaired renal function is a well-known side effect of lithium, which has been used since the 1950s to treat acute episodes of mania and as maintenance therapy for bipolar disorder. In the largest study to date of the renal effects of lithium, researchers found that the duration of lithium treatment did not correlate with glomerular filtration rate (GFR).