ADT for Prostate Cancer May Increase Cataract Risk

Share this article:

Androgen deprivation therapy (ADT) may increase the risk of cataracts among men with prostate cancer (PCa), according to the findings of a large study.

ADT can cause weight gain, dyslipidemia, and insulin resistance. These metabolic abnormalities also have been linked with cataracts, leading researchers to question whether this ophthalmologic condition could be another adverse consequence of ADT use. Jennifer Beebe-Dimmer, PhD, of the Karmanos Cancer Institute in Detroit, and colleagues used the Surveillance, Epidemiology and End Results (SEER) database to estimate cataract risk associated with ADT among 65,852 men with PCa who had received such therapy (at least one dose of a gonadotropin-releasing hormone agonist or orchiectomy) within six months after being diagnosed.

After comparing outcomes with men not treated with ADT, the investigators found that gonadotropin-releasing hormone agonist use was associated with a 9% increase in cataract incidence, which they described as “modest” in an online report in Annals of Epidemiology. A 26% increase in cataract incidence was noted among men who had no history of cataracts prior to undergoing orchiectomy.

Share this article:
You must be a registered member of RUN to post a comment.
close

Next Article in Prostate Cancer

More in Prostate Cancer

Early Adjuvant Radiotherapy Benefits Selected Prostate Cancer Patients

Early Adjuvant Radiotherapy Benefits Selected Prostate Cancer Patients ...

Radiotherapy given within 6 months of radical prostatectomy reduces cancer-specific mortality in men with highly aggressive disease.

Sexual Function Preserved in Prostate Cancer Combination Therapy

Sexual Function Preserved in Prostate Cancer Combination Therapy

High rates of preserved sexual function with combination beam plus brachytherapy.

Radical Prostatectomy Rates Rising

Radical Prostatectomy Rates Rising

Utilization rates jumped by double digits across prostate cancer risk groups from 2004 to 2011.