Acute Kidney Injury

RAS Inhibitor Therapy May Prolong Survival After Acute Kidney Injury

RAS Inhibitor Therapy May Prolong Survival After Acute Kidney Injury

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In a Canadian study of patients who experienced AKI during hospitalization, treatment with an ACEI or ARB within 6 months of discharge was associated with a 15% lower risk for death after 2 years.

Angiotensin-converting enzyme inhibitor or angiotensin receptor blocker use linked with decreased mortality after inpatient acute kidney injury.

1. In this retrospective cohort study looking at patients admitted to hospital with acute kidney injury, use of angiotensin-converting enzyme inhibitor or angiotensin receptor blocker within six months was associated with decreased mortality. 2. Angiotensin-converting enzyme inhibitor or angiotensin receptor blocker use was also associated with increased risk of hospitalization for a renal cause (hyperkalemia, []

Acute Kidney Injury Increases Dementia Risk

Acute Kidney Injury Increases Dementia Risk

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In a propensity score-matched analysis, AKI was associated with a 3.4-fold greater risk of dementia.

Statins Reduce Mortality Risk in Dialysis-Requiring AKI

Statins Reduce Mortality Risk in Dialysis-Requiring AKI

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Statin use vs non-use among patients hospitalized with dialysis-requiring acute kidney injury is associated with decreased risks of 1-year and in-hospital all-cause mortality, a study found.

Acute Kidney Injury Linked to Lower Bicarbonate Levels

Acute Kidney Injury Linked to Lower Bicarbonate Levels

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Individuals with a serum bicarbonate level below 24 mEq/L have a 2-fold increased risk of AKI compared with those with a level of 25-28 mEq/L.

Early and delayed renal-replacement therapy for septic shock associated acute kidney injury show similar mortality: the IDEAL-ICU trial

1. Among patients with septic shock and acute kidney injury (AKI), there was no significant difference in 90-day mortality between early (within 12 hours) and delayed (after 48 hours) initiation of renal-replacement therapy (RRT). 2. Patients in the delayed group had significantly more days free from RRT, with no significant differences compared to the early []

RRT Timing for Sepsis-Related AKI Does Not Affect Mortality Risk

RRT Timing for Sepsis-Related AKI Does Not Affect Mortality Risk

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More than half of patients died prematurely, regardless of whether they received early or delayed RRT.

Acute Kidney Injury Risk Lower With Ultra-Low Contrast Volume Use

Acute Kidney Injury Risk Lower With Ultra-Low Contrast Volume Use

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Use of ultra-low contrast volume during percutaneous coronary intervention was associated with 32% decreased odds of acute kidney injury, investigators report.

Substantial Increase in AKI Incidence Reported

Substantial Increase in AKI Incidence Reported

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Stage 1 acute kidney injury accounted for the biggest growth in incidence rate.

Uric Acid Predicts AKI Risk After Cardiac Surgery

Uric Acid Predicts AKI Risk After Cardiac Surgery

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Serum uric acid levels above the median prior to cardiac surgery is independently associated with 5.5-fold increased odds of postoperative acute kidney injury.

Sodium Bicarbonate for Severe Acidemia Beneficial in AKI

Sodium Bicarbonate for Severe Acidemia Beneficial in AKI

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Sodium bicarbonate infusions decreased the risk of death or organ failure among ICU patients with acute kidney injury and severe metabolic acidemia.

Postop AKI Linked to Pre-Surgery Proteinuria

Postop AKI Linked to Pre-Surgery Proteinuria

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Proteinuria at the time of surgery is associated with an elevated risk of postoperative acute kidney injury and 30-day unplanned readmission.

Nitric Oxide Cuts Kidney Injury After Long Cardiac Surgery

Nitric Oxide Cuts Kidney Injury After Long Cardiac Surgery

Reduced kidney injury, better kidney function seen after prolonged cardiopulmonary bypass.

Many AKI Reports Linked to Drugs Not Recognized as Nephrotoxic

Many AKI Reports Linked to Drugs Not Recognized as Nephrotoxic

According to the authors, this is the first study to identify medications most commonly reported for a specific adverse reaction using the FAERS database.

Older Age, ICU, Poor Renal Function Up Opioid Overdose

Older Age, ICU, Poor Renal Function Up Opioid Overdose

For hospitalized patients, risk also increased for those receiving 3 or more CNS antidepressants.

Acute Kidney Injury Increases Heart Failure Risk

Acute Kidney Injury Increases Heart Failure Risk

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If the study findings are confirmed, earlier detection of heart failure could save lives, according to researchers.

Early Post-Op APAP Exposure May Cut AKI Risk in Peds Cardiac Sx

Early Post-Op APAP Exposure May Cut AKI Risk in Peds Cardiac Sx

Early acetaminophen exposure after pediatric cardiac surgery may reduce rate of acute kidney injury.

Restricting Fluids Post Abdominal Surgery Doesn't Up Survival

Restricting Fluids Post Abdominal Surgery Doesn't Up Survival

Fluid restriction has no impact on disability-free survival; increases risk of acute kidney injury

Cystatin C Tied to Cumulative Hearing Impairment

Cystatin C Tied to Cumulative Hearing Impairment

Cystatin C as biomarker, kidney function marker linked to 20-year cumulative incidence of HI.

Mortality Risk After Community-Acquired AKI Lower in Women

Mortality Risk After Community-Acquired AKI Lower in Women

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Investigators report that female vs male sex was associated with a significant 14% lower mortality risk following an episode of community-acquired acute kidney injury.

Outpatient AKI Is a Risk Factor for Death, Adverse Renal Outcomes

Outpatient AKI Is a Risk Factor for Death, Adverse Renal Outcomes

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In the most comprehensive study of its kind, investigators find that acute kidney injury not requiring hospitalization is associated with a 90% increased mortality risk.

Caffeine May Prevent Acute Kidney Injury in Preterm Neonates

Caffeine May Prevent Acute Kidney Injury in Preterm Neonates

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In a large study, caffeine administration to neonates born before 33 weeks' gestation reduced their odds of experiencing AKI by a significant 80%.

Acute Kidney Injury Hospitalizations Increased 2000 to 2014

Acute Kidney Injury Hospitalizations Increased 2000 to 2014

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AKI hospitalizations were 4 times more likely among patients with diabetes.

Balanced crystalloids decreases adverse kidney events compared to saline among critically ill patients: The SMART trial

1. Use of balanced crystalloids (lactated Ringers or Plasma-Lyte A) was associated with a significant reduction in acute kidney injury events compared to normal saline among intensive care unit (ICU) patients. 2. Use of balanced crystalloids was also associated with lower though nonsignificant in-hospital mortality at 30-days after admission. Evidence Rating Level: 1 (Excellent) Study []

Ultra-low Contrast Volume May Protect Kidneys in Advanced CKD

Ultra-low Contrast Volume May Protect Kidneys in Advanced CKD

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No patient had a 25% or greater rise in serum creatinine 48 hours after receiving a median 13 mL of contrast for diagnostic coronary angiography, with an additional 13 mL for percutaneous coronary intervention.

Acute Kidney Injury Increases Risk for Hypoglycemia in Diabetes Pts

Acute Kidney Injury Increases Risk for Hypoglycemia in Diabetes Pts

AKI associated with 27% increased risk of hypoglycemia among patients with diabetes.

High Risk of AKI After Non-Kidney Transplants in Children

High Risk of AKI After Non-Kidney Transplants in Children

High risk of AKI in first year after non-kidney solid organ transplant; in turn, increases CKD risk.

Early RRT for Acute Kidney Injury Not Superior

Early RRT for Acute Kidney Injury Not Superior

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Early and late initiation of renal replacement therapy for AKI in critically ill patients are associated with similar long-term risks of death, chronic kidney disease, and end-stage renal disease.

AKI With <i>C. difficile</i> Admissions Increasing

AKI With C. difficile Admissions Increasing

Though hospital admission rates have increased, inpatient death has improved from 2003 to 2012.

Acute Kidney Injury in CCU Patients Linked to Cystatin C

Acute Kidney Injury in CCU Patients Linked to Cystatin C

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Among patients admitted to a coronary care unit, the highest quartile of serum cystatin C levels was associated with a 9.6-fold increased risk of AKI compared with the lowest quartile.

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