Acute Kidney Injury

Timing of Renal Replacement Therapy Initiation in AKI

Timing of Renal Replacement Therapy Initiation in AKI

Evidence to date provides no clear answer as to whether early or delayed RRT is the best approach.

AKI Predictors in PE Patients Identified

AKI Predictors in PE Patients Identified

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Chronic kidney disease and anemia are associated with an increased risk for acute kidney injury in patients with pulmonary embolism.

Children With Diabetic Ketoacidosis at High Risk of AKI

Children With Diabetic Ketoacidosis at High Risk of AKI

Of the children who developed acute kidney injury, 34.9% had stage 1, 45.3% had stage 2, and 19.8% had stage 3.

Marathon Runners May Develop AKI, Tubular Injury

Marathon Runners May Develop AKI, Tubular Injury

An increase in injury and repair biomarker levels suggests structural damage to renal tubules occurring after marathon.

Chronic Kidney Disease More Likely in PPI Users

Chronic Kidney Disease More Likely in PPI Users

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Proton pump inhibitors need not first cause acute kidney injury for CKD risk to be elevated.

Furosemide With Matched Hydration Prevents Contrast Nephropathy

Furosemide With Matched Hydration Prevents Contrast Nephropathy

Compared with control treatment, RenalGuard therapy correlated with significantly reduced CI-AKI, as well as a reduced need for renal replacement therapy.

Kidney Function Predicts Hospital Discharge, Mortality After Stroke

Kidney Function Predicts Hospital Discharge, Mortality After Stroke

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Patients with an eGFR below 60 mL/min/1.73 m2 were more likely to die in the hospital or be discharged to hospice.

Platelet Counts Linked to AKI Severity in Pediatric Open-Heart Surgery

Platelet Counts Linked to AKI Severity in Pediatric Open-Heart Surgery

There is a strong association between magnified nadir platelet counts and the severity of AKI.

Previous AKI Episode Associated With Pregnancy Risks

Previous AKI Episode Associated With Pregnancy Risks

Women with r-AKI had increased rates of preeclampsia and premature infant births, compared with controls.

AKI Is a Risk Factor for Delirium, Coma in Critically Ill

AKI Is a Risk Factor for Delirium, Coma in Critically Ill

The researchers found that stage 2 acute kidney injury was associated with increased risk of delirium and coma as was stage 3 acute kidney injury.

Severe AKI in Young ICU Patients Predicts Higher Mortality

Severe AKI in Young ICU Patients Predicts Higher Mortality

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The condition also is associated with greater use of renal-replacement therapy and mechanical ventilation.

Early RRT for AKI May Lower Risk of Dialysis Dependence

Early RRT for AKI May Lower Risk of Dialysis Dependence

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It also may shorten intensive care unit and hospital length of stay versus late RRT in critically ill patients, meta-analysis reveals.

Higher Uric Acid Levels in Critically Ill Patients Up AKI Risk

Higher Uric Acid Levels in Critically Ill Patients Up AKI Risk

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Odds of acute kidney injury increases by 29% with each 1 mg/dL increment in uric acid level at ICU admission.

Factors Linked to Worse Post-Surgical Kidney Function ID'd

Factors Linked to Worse Post-Surgical Kidney Function ID'd

Factors including low preoperative mean arterial BP tied to increases in eGFR, kidney injury.

Progress to More Nuanced Medicine

Progress to More Nuanced Medicine

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Medicine is making progress to refine patient care.

Genetic Loci Linked to Acute Kidney Injury

Genetic Loci Linked to Acute Kidney Injury

Four single-nucleotide polymorphisms at two loci identified in discovery, replication populations.

Hyperphosphatemia Linked With Mortality in Septic AKI

Hyperphosphatemia Linked With Mortality in Septic AKI

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Hyperphosphatemia was associated with more than double the risk of death from any cause.

Better AKI Patient Survival Linked to Negative Fluid Balance

Better AKI Patient Survival Linked to Negative Fluid Balance

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The mortality rate among patients with negative fluid balance was just 7.4%, compared with 43.5% for patients with a positive fluid balance.

Acute Kidney Injury Progression Predicted by Urinary Biomarkers

Acute Kidney Injury Progression Predicted by Urinary Biomarkers

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Study identifies 3 biomarkers that could detect increasing risk of worsening AKI in patients with acute cardiorenal syndrome.

More Intensive Renal Replacement Therapy Possibly Harmful

More Intensive Renal Replacement Therapy Possibly Harmful

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This approach is associated with lower urine output during the first 7 days of therapy.

Drug Combinations May Increase Acute Kidney Injury Risk

Drug Combinations May Increase Acute Kidney Injury Risk

NSAIDs + diuretics with or without additional renin-angiotensin aldosterone agents demonstrated the strongest level of evidence.

Acute Kidney Injury May Up Long-Term Risk of Cardiovascular Mortality

Acute Kidney Injury May Up Long-Term Risk of Cardiovascular Mortality

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In a meta-analysis, AKI was associated with an 86% increased risk of CV-related death and 38% increased risk of other major CV events.

FDA Strengthens AKI Warning for Some SGLT2 Inhibitors

FDA Strengthens AKI Warning for Some SGLT2 Inhibitors

The Food and Drug Administration (FDA) announced it is strengthening the current warning about the risk of acute kidney injury for drug products containing canagliflozin (Invokana, Invokamet) and dapagliflozin (Farxiga, Xigduo XR).

CKD Progression After Acute Kidney Injury Characterized

CKD Progression After Acute Kidney Injury Characterized

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Male gender, diabetes, and renal function decline at 90 days implicated as risk factors; patients rarely progress to end-stage renal disease.

Fluid Overload at RRT Initiation Ups AKI Patients' Long-Term Mortality

Fluid Overload at RRT Initiation Ups AKI Patients' Long-Term Mortality

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Japanese study demonstrates a 2-fold increased risk of death from any cause.

In-Hospital Mortality From Dialysis-Requiring AKI Declining

In-Hospital Mortality From Dialysis-Requiring AKI Declining

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Patients were 40% less likely to die in 2011 compared with 2001, study finds.

Critically Ill Acute Kidney Injury Patients Benefit From Early RRT

Critically Ill Acute Kidney Injury Patients Benefit From Early RRT

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Study demonstrates improved 90-day survival and greater likelihood of recovering renal function.

Risk Factors ID'd for Early Mortality After Starting CRRT

Risk Factors ID'd for Early Mortality After Starting CRRT

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High FiO2 and norepinephrine in AKI patients increases their risk of death within 24 hours of being placed on continuous renal replacement therapy.

No Survival Advantage With Early Renal-Replacement Therapy in AKI

No Survival Advantage With Early Renal-Replacement Therapy in AKI

Mortality no different for early versus delayed strategy for patients with severe acute kidney injury.

AKI After RCC Surgery On the Rise

AKI After RCC Surgery On the Rise

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Nearly 6% of patients who underwent partial or radical nephrectomy between 1998 and 2010 developed AKI.

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