Acute Kidney Injury

Sodium Bicarbonate for Severe Acidemia Beneficial in AKI

Sodium Bicarbonate for Severe Acidemia Beneficial in AKI

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Sodium bicarbonate infusions decreased the risk of death or organ failure among ICU patients with acute kidney injury and severe metabolic acidemia.

Postop AKI Linked to Pre-Surgery Proteinuria

Postop AKI Linked to Pre-Surgery Proteinuria

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Proteinuria at the time of surgery is associated with an elevated risk of postoperative acute kidney injury and 30-day unplanned readmission.

Nitric Oxide Cuts Kidney Injury After Long Cardiac Surgery

Nitric Oxide Cuts Kidney Injury After Long Cardiac Surgery

Reduced kidney injury, better kidney function seen after prolonged cardiopulmonary bypass.

Many AKI Reports Linked to Drugs Not Recognized as Nephrotoxic

Many AKI Reports Linked to Drugs Not Recognized as Nephrotoxic

According to the authors, this is the first study to identify medications most commonly reported for a specific adverse reaction using the FAERS database.

Older Age, ICU, Poor Renal Function Up Opioid Overdose

Older Age, ICU, Poor Renal Function Up Opioid Overdose

For hospitalized patients, risk also increased for those receiving 3 or more CNS antidepressants.

Acute Kidney Injury Increases Heart Failure Risk

Acute Kidney Injury Increases Heart Failure Risk

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If the study findings are confirmed, earlier detection of heart failure could save lives, according to researchers.

Early Post-Op APAP Exposure May Cut AKI Risk in Peds Cardiac Sx

Early Post-Op APAP Exposure May Cut AKI Risk in Peds Cardiac Sx

Early acetaminophen exposure after pediatric cardiac surgery may reduce rate of acute kidney injury.

Restricting Fluids Post Abdominal Surgery Doesn't Up Survival

Restricting Fluids Post Abdominal Surgery Doesn't Up Survival

Fluid restriction has no impact on disability-free survival; increases risk of acute kidney injury

Cystatin C Tied to Cumulative Hearing Impairment

Cystatin C Tied to Cumulative Hearing Impairment

Cystatin C as biomarker, kidney function marker linked to 20-year cumulative incidence of HI.

Mortality Risk After Community-Acquired AKI Lower in Women

Mortality Risk After Community-Acquired AKI Lower in Women

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Investigators report that female vs male sex was associated with a significant 14% lower mortality risk following an episode of community-acquired acute kidney injury.

Outpatient AKI Is a Risk Factor for Death, Adverse Renal Outcomes

Outpatient AKI Is a Risk Factor for Death, Adverse Renal Outcomes

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In the most comprehensive study of its kind, investigators find that acute kidney injury not requiring hospitalization is associated with a 90% increased mortality risk.

Caffeine May Prevent Acute Kidney Injury in Preterm Neonates

Caffeine May Prevent Acute Kidney Injury in Preterm Neonates

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In a large study, caffeine administration to neonates born before 33 weeks' gestation reduced their odds of experiencing AKI by a significant 80%.

Acute Kidney Injury Hospitalizations Increased 2000 to 2014

Acute Kidney Injury Hospitalizations Increased 2000 to 2014

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AKI hospitalizations were 4 times more likely among patients with diabetes.

Balanced crystalloids decreases adverse kidney events compared to saline among critically ill patients: The SMART trial

1. Use of balanced crystalloids (lactated Ringers or Plasma-Lyte A) was associated with a significant reduction in acute kidney injury events compared to normal saline among intensive care unit (ICU) patients. 2. Use of balanced crystalloids was also associated with lower though nonsignificant in-hospital mortality at 30-days after admission. Evidence Rating Level: 1 (Excellent) Study []

Ultra-low Contrast Volume May Protect Kidneys in Advanced CKD

Ultra-low Contrast Volume May Protect Kidneys in Advanced CKD

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No patient had a 25% or greater rise in serum creatinine 48 hours after receiving a median 13 mL of contrast for diagnostic coronary angiography, with an additional 13 mL for percutaneous coronary intervention.

Acute Kidney Injury Increases Risk for Hypoglycemia in Diabetes Pts

Acute Kidney Injury Increases Risk for Hypoglycemia in Diabetes Pts

AKI associated with 27% increased risk of hypoglycemia among patients with diabetes.

High Risk of AKI After Non-Kidney Transplants in Children

High Risk of AKI After Non-Kidney Transplants in Children

High risk of AKI in first year after non-kidney solid organ transplant; in turn, increases CKD risk.

Early RRT for Acute Kidney Injury Not Superior

Early RRT for Acute Kidney Injury Not Superior

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Early and late initiation of renal replacement therapy for AKI in critically ill patients are associated with similar long-term risks of death, chronic kidney disease, and end-stage renal disease.

AKI With <i>C. difficile</i> Admissions Increasing

AKI With C. difficile Admissions Increasing

Though hospital admission rates have increased, inpatient death has improved from 2003 to 2012.

Acute Kidney Injury in CCU Patients Linked to Cystatin C

Acute Kidney Injury in CCU Patients Linked to Cystatin C

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Among patients admitted to a coronary care unit, the highest quartile of serum cystatin C levels was associated with a 9.6-fold increased risk of AKI compared with the lowest quartile.

Kidney Risks Differ Among Oral Anticoagulant Drugs for AFib

Kidney Risks Differ Among Oral Anticoagulant Drugs for AFib

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Dabigatran and rivaroxaban were associated with lower risks of adverse renal outcomes compared with warfarin.

Acute Kidney Injury Predicts Heart Failure

Acute Kidney Injury Predicts Heart Failure

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In a study of hospitalized US veterans, AKI was associated with a 23% increased risk of heart failure compared with the absence of AKI.

New Model Improves Predictions of Advanced CKD Following AKI

New Model Improves Predictions of Advanced CKD Following AKI

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The model was based on 6 variables readily obtained at hospital discharge.

IV Sodium Bicarbonate Does Not Reduce AKI Risk After Angiography

IV Sodium Bicarbonate Does Not Reduce AKI Risk After Angiography

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Contrast-associated acute kidney injury occurred in 9.5% and 9.1% of patients receiving IV sodium bicarbonate and acetylcysteine, respectively, rates which did not differ significantly from the 8.3% rate among those receiving IV sodium chloride.

Acute Kidney Injury After Cardiac Revascularization on the Rise

Acute Kidney Injury After Cardiac Revascularization on the Rise

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From 2004 to 2012, the incidence of AKI increased from 4.9% to 14.2% among CABG patients and from 2.7% to 8.8% among PCI patients.

AKI More Likely After Intracoronary Versus IV Contrast Delivery

AKI More Likely After Intracoronary Versus IV Contrast Delivery

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In a phase 3 trial, acute kidney injury developed in 13.2% of patients undergoing invasive coronary angiography compared with 5.6% of those undergoing computed tomography angiography.

ESRD Frequently Follows Dialysis-Dependent AKI

ESRD Frequently Follows Dialysis-Dependent AKI

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In a study, end-stage renal disease developed in 56% of patients discharged from a hospital with acute kidney injury requiring dialysis.

AKI at 12 and 24 Hours After PCI Independently Ups Death Risk

AKI at 12 and 24 Hours After PCI Independently Ups Death Risk

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Timing of AKI after urgent percutaneous coronary intervention affects risk of significant kidney function loss 1 year after the procedure.

Intensive Blood Pressure Control May Not Benefit CKD Patients

Intensive Blood Pressure Control May Not Benefit CKD Patients

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Post hoc analysis of SPRINT finds no significant difference in the incidence of fatal and nonfatal cardiovascular events among patients with moderate-to-advanced chronic kidney disease.

VTE Prophylaxis Inadequate for Acute Kidney Injury Patients

VTE Prophylaxis Inadequate for Acute Kidney Injury Patients

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In a study, AKI sufferers had an increased rate of venous thromboembolism whether they receive heparin prophylaxis or not.

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