Acute Kidney Injury

Drug Combinations May Increase Acute Kidney Injury Risk

Drug Combinations May Increase Acute Kidney Injury Risk

NSAIDs + diuretics with or without additional renin-angiotensin aldosterone agents demonstrated the strongest level of evidence.

Acute Kidney Injury May Up Long-Term Risk of Cardiovascular Mortality

Acute Kidney Injury May Up Long-Term Risk of Cardiovascular Mortality

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In a meta-analysis, AKI was associated with an 86% increased risk of CV-related death and 38% increased risk of other major CV events.

FDA Strengthens AKI Warning for Some SGLT2 Inhibitors

FDA Strengthens AKI Warning for Some SGLT2 Inhibitors

The Food and Drug Administration (FDA) announced it is strengthening the current warning about the risk of acute kidney injury for drug products containing canagliflozin (Invokana, Invokamet) and dapagliflozin (Farxiga, Xigduo XR).

CKD Progression After Acute Kidney Injury Characterized

CKD Progression After Acute Kidney Injury Characterized

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Male gender, diabetes, and renal function decline at 90 days implicated as risk factors; patients rarely progress to end-stage renal disease.

Fluid Overload at RRT Initiation Ups AKI Patients' Long-Term Mortality

Fluid Overload at RRT Initiation Ups AKI Patients' Long-Term Mortality

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Japanese study demonstrates a 2-fold increased risk of death from any cause.

In-Hospital Mortality From Dialysis-Requiring AKI Declining

In-Hospital Mortality From Dialysis-Requiring AKI Declining

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Patients were 40% less likely to die in 2011 compared with 2001, study finds.

Critically Ill Acute Kidney Injury Patients Benefit From Early RRT

Critically Ill Acute Kidney Injury Patients Benefit From Early RRT

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Study demonstrates improved 90-day survival and greater likelihood of recovering renal function.

Risk Factors ID'd for Early Mortality After Starting CRRT

Risk Factors ID'd for Early Mortality After Starting CRRT

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High FiO2 and norepinephrine in AKI patients increases their risk of death within 24 hours of being placed on continuous renal replacement therapy.

No Survival Advantage With Early Renal-Replacement Therapy in AKI

No Survival Advantage With Early Renal-Replacement Therapy in AKI

Mortality no different for early versus delayed strategy for patients with severe acute kidney injury.

AKI After RCC Surgery On the Rise

AKI After RCC Surgery On the Rise

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Nearly 6% of patients who underwent partial or radical nephrectomy between 1998 and 2010 developed AKI.

Hospital- vs Community-Acquired AKI

Hospital- vs Community-Acquired AKI

Poor long-term outcomes found even in patients with community-acquired AKI but not hospitalized.

No Benefit, Kidney Risk Found for Perioperative Statins

No Benefit, Kidney Risk Found for Perioperative Statins

Statins don't prevent complications and may cause acute kidney injury, researchers report.

ACEI/ARBs Improve AMI Outcomes Regardless of Kidney Function

ACEI/ARBs Improve AMI Outcomes Regardless of Kidney Function

Treatment linked to improved long-term survival, regardless of underlying kidney function.

CMX-2043 Did Not Reduce Contrast-Induced Nephropathy

CMX-2043 Did Not Reduce Contrast-Induced Nephropathy

CARIN trial reported no significant differences in acute kidney injury incidence between novel compound CMX-2043 and placebo.

Aliskiren/Enalapril Combo Results in More Harms in Heart Failure

Aliskiren/Enalapril Combo Results in More Harms in Heart Failure

The addition of aliskiren to enalapril led to more adverse events in patients with chronic heart failure without an increase in benefit.

ACE Inhibitors, ARBs Comparable for Diabetic Retinopathy Patients

ACE Inhibitors, ARBs Comparable for Diabetic Retinopathy Patients

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Study finds no significant difference in the rates of all-cause mortality, major cardiac events, and hospital admission with hyperkalemia or AKI.

World Kidney Day 2016 Focuses on Disease in Childhood

World Kidney Day 2016 Focuses on Disease in Childhood

10% of the population worldwide is impacted by some form of kidney damage.

Peri-Op Statin Therapy Does Not Prevent AKI After Cardiac Surgery

Peri-Op Statin Therapy Does Not Prevent AKI After Cardiac Surgery

The trial was stopped for futility after 615 patients completed the study.

Peri-Op Statin Therapy Does Not Prevent AKI After Cardiac Surgery

Peri-Op Statin Therapy Does Not Prevent AKI After Cardiac Surgery

The trial was stopped for futility after 615 patients completed the study.

AKI After Cardiac Surgery Linked to Worse Survival, Renal Outcomes

AKI After Cardiac Surgery Linked to Worse Survival, Renal Outcomes

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Acute kidney injury increased the likelihood of advanced chronic kidney disease in elderly patients.

Statin Use May Raise Kidney Disease Risk

Statin Use May Raise Kidney Disease Risk

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Statin users had 30% increased odds of acute kidney injury and 36% increased odds of chronic kidney disease compared with non-users.

IV Iron Safe for Treating Anemia in Acute Kidney Injury Patients

IV Iron Safe for Treating Anemia in Acute Kidney Injury Patients

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In a case-control study, the treatment did not adversely affect mortality or recovery from AKI.

AKI Diagnostic Testing May Be Excessive

AKI Diagnostic Testing May Be Excessive

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Results of some urine and blood tests are unlikely to affect diagnosis or management of acute kidney injury.

CKD Risk Following Inpatient Acute Kidney Injury Characterized

CKD Risk Following Inpatient Acute Kidney Injury Characterized

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Even mild AKI with rapid recovery is associated with increased risk of chronic kidney disease stage 3 or higher.

Long-Term Cardiovascular Mortality Linked to Post-Op AKI, CKD

Long-Term Cardiovascular Mortality Linked to Post-Op AKI, CKD

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Even surgery patients with stage 1 AKI without true organ damage had a 43% increase in cardiovascular mortality risk within 10 years compared with patients with no kidney disease.

CKD Progression to Stage 4 Predicts Increased Death Risk

CKD Progression to Stage 4 Predicts Increased Death Risk

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CKD progression from stage 3 to stage 4 also was associated with increased risks of acute kidney injury and hospitalization.

Renal Biomarkers Predict Diabetes Outcomes

Renal Biomarkers Predict Diabetes Outcomes

AKI, albuminuria, eGFR considered separately or together can predict adverse outcomes in diabetes.

Tenofovir-Linked Acute Kidney Injury Common in HIV

Tenofovir-Linked Acute Kidney Injury Common in HIV

Fewer than half of patients with TFD-linked AKI had renal function recovery after drug withdrawal.

Acute Kidney Injury More Likely in African Americans

Acute Kidney Injury More Likely in African Americans

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Increased risk observed in the VA health system unlikely to be fully explained by disparities in access to care.

Acute Kidney Injury Raises Heart Failure Risk

Acute Kidney Injury Raises Heart Failure Risk

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AKI is independently associated with a 27% increased risk of heart failure, according to a study of hospitalized U.S. veterans.

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