Dialysis for AKI Does Not Hike Risk of Major Cardiovascular Events
Absence of association observed in patients with normal or near-normal baseline estimated glomerular filtration rate.
DALLAS—Treatment of acute kidney injury (AKI) with temporary dialysis in hospitalized patients with normal or near-normal estimated glomerular filtration rate is not associated with an increased risk for subsequent major adverse cardiovascular events (MACE), according to study findings presented at the National Kidney Foundation's 2015 Spring Clinical Meetings.
Bolanle A. Omotoso, MD, of the University of Virginia Medical Center in Charlottesville, and colleagues conducted an observational cohort study of 125,880 adults admitted to the hospital from January 1, 2002 to December 31, 2012. All had an estimated glomerular filtration rate of 60 mL/min/1.73 m2 or higher. AKI developed in 24,631 (19.57%). The researchers propensity score matched 253 AKI patients who received temporary dialysis with 759 AKI patients who did not.
After a median follow-up 299 days, the researchers observed no significant difference between the groups in the risk of MACE, defined as subsequent admission for myocardial infarction, transient ischemic attack, stroke, and heart failure.