Acute Kidney Injury News Archive
High risk of AKI in first year after non-kidney solid organ transplant; in turn, increases CKD risk.
Early and late initiation of renal replacement therapy for AKI in critically ill patients are associated with similar long-term risks of death, chronic kidney disease, and end-stage renal disease.
Though hospital admission rates have increased, inpatient death has improved from 2003 to 2012.
Among patients admitted to a coronary care unit, the highest quartile of serum cystatin C levels was associated with a 9.6-fold increased risk of AKI compared with the lowest quartile.
Dabigatran and rivaroxaban were associated with lower risks of adverse renal outcomes compared with warfarin.
In a study of hospitalized US veterans, AKI was associated with a 23% increased risk of heart failure compared with the absence of AKI.
The model was based on 6 variables readily obtained at hospital discharge.
Contrast-associated acute kidney injury occurred in 9.5% and 9.1% of patients receiving IV sodium bicarbonate and acetylcysteine, respectively, rates which did not differ significantly from the 8.3% rate among those receiving IV sodium chloride.
From 2004 to 2012, the incidence of AKI increased from 4.9% to 14.2% among CABG patients and from 2.7% to 8.8% among PCI patients.
In a phase 3 trial, acute kidney injury developed in 13.2% of patients undergoing invasive coronary angiography compared with 5.6% of those undergoing computed tomography angiography.
In a study, end-stage renal disease developed in 56% of patients discharged from a hospital with acute kidney injury requiring dialysis.
Timing of AKI after urgent percutaneous coronary intervention affects risk of significant kidney function loss 1 year after the procedure.
Post hoc analysis of SPRINT finds no significant difference in the incidence of fatal and nonfatal cardiovascular events among patients with moderate-to-advanced chronic kidney disease.
In a study, AKI sufferers had an increased rate of venous thromboembolism whether they receive heparin prophylaxis or not.
Three-quarters of patients hospitalized with acute kidney injury in Alberta, Canada did not visit a kidney specialist within 12 months of discharge.
Elevated levels of the two proteins can predict risk of acute kidney injury.
Risk of AKI in hospitalized children higher than with IV vancomycin, other antipseudomonal -lactam
AKI occurred with similar frequency among patients who did and did not receive contrast medium.
Findings do not suggest an increased risk of AKI associated with SGLT2 inhibitor use in patients with type 2 diabetes.
Higher mortality was seen in association with an emergency department discharge with acute kidney injury vs no acute kidney injury.
Myocardial infarction patients who underwent percutaneous coronary intervention had an AKI rate similar to those who did not have the procedure.
Chronic kidney disease and anemia are associated with an increased risk for acute kidney injury in patients with pulmonary embolism.
Of the children who developed acute kidney injury, 34.9% had stage 1, 45.3% had stage 2, and 19.8% had stage 3.
An increase in injury and repair biomarker levels suggests structural damage to renal tubules occurring after marathon.
Proton pump inhibitors need not first cause acute kidney injury for CKD risk to be elevated.
Compared with control treatment, RenalGuard therapy correlated with significantly reduced CI-AKI, as well as a reduced need for renal replacement therapy.
Patients with an eGFR below 60 mL/min/1.73 m2 were more likely to die in the hospital or be discharged to hospice.
There is a strong association between magnified nadir platelet counts and the severity of AKI.
Women with r-AKI had increased rates of preeclampsia and premature infant births, compared with controls.
The researchers found that stage 2 acute kidney injury was associated with increased risk of delirium and coma as was stage 3 acute kidney injury.
The condition also is associated with greater use of renal-replacement therapy and mechanical ventilation.
It also may shorten intensive care unit and hospital length of stay versus late RRT in critically ill patients, meta-analysis reveals.
Odds of acute kidney injury increases by 29% with each 1 mg/dL increment in uric acid level at ICU admission.
Factors including low preoperative mean arterial BP tied to increases in eGFR, kidney injury.
Four single-nucleotide polymorphisms at two loci identified in discovery, replication populations.
Hyperphosphatemia was associated with more than double the risk of death from any cause.
The mortality rate among patients with negative fluid balance was just 7.4%, compared with 43.5% for patients with a positive fluid balance.
Study identifies 3 biomarkers that could detect increasing risk of worsening AKI in patients with acute cardiorenal syndrome.
This approach is associated with lower urine output during the first 7 days of therapy.
NSAIDs + diuretics with or without additional renin-angiotensin aldosterone agents demonstrated the strongest level of evidence.
In a meta-analysis, AKI was associated with an 86% increased risk of CV-related death and 38% increased risk of other major CV events.
The Food and Drug Administration (FDA) announced it is strengthening the current warning about the risk of acute kidney injury for drug products containing canagliflozin (Invokana, Invokamet) and dapagliflozin (Farxiga, Xigduo XR).
Male gender, diabetes, and renal function decline at 90 days implicated as risk factors; patients rarely progress to end-stage renal disease.
Japanese study demonstrates a 2-fold increased risk of death from any cause.
High FiO2 and norepinephrine in AKI patients increases their risk of death within 24 hours of being placed on continuous renal replacement therapy.
Study demonstrates improved 90-day survival and greater likelihood of recovering renal function.
Patients were 40% less likely to die in 2011 compared with 2001, study finds.
Mortality no different for early versus delayed strategy for patients with severe acute kidney injury.
Nearly 6% of patients who underwent partial or radical nephrectomy between 1998 and 2010 developed AKI.
Poor long-term outcomes found even in patients with community-acquired AKI but not hospitalized.
Statins don't prevent complications and may cause acute kidney injury, researchers report.
Treatment linked to improved long-term survival, regardless of underlying kidney function.
CARIN trial reported no significant differences in acute kidney injury incidence between novel compound CMX-2043 and placebo.
The addition of aliskiren to enalapril led to more adverse events in patients with chronic heart failure without an increase in benefit.
Study finds no significant difference in the rates of all-cause mortality, major cardiac events, and hospital admission with hyperkalemia or AKI.
10% of the population worldwide is impacted by some form of kidney damage.
The trial was stopped for futility after 615 patients completed the study.
Acute kidney injury increased the likelihood of advanced chronic kidney disease in elderly patients.
Statin users had 30% increased odds of acute kidney injury and 36% increased odds of chronic kidney disease compared with non-users.
In a case-control study, the treatment did not adversely affect mortality or recovery from AKI.
Results of some urine and blood tests are unlikely to affect diagnosis or management of acute kidney injury.
Even mild AKI with rapid recovery is associated with increased risk of chronic kidney disease stage 3 or higher.
Even surgery patients with stage 1 AKI without true organ damage had a 43% increase in cardiovascular mortality risk within 10 years compared with patients with no kidney disease.
CKD progression from stage 3 to stage 4 also was associated with increased risks of acute kidney injury and hospitalization.
AKI, albuminuria, eGFR considered separately or together can predict adverse outcomes in diabetes.
Fewer than half of patients with TFD-linked AKI had renal function recovery after drug withdrawal.
Increased risk observed in the VA health system unlikely to be fully explained by disparities in access to care.
AKI is independently associated with a 27% increased risk of heart failure, according to a study of hospitalized U.S. veterans.
AKI developed in 2.1% of operations and was more common after major, open, and acute surgeries.
Risk of developing acute kidney injury similar with buffered crystalloid, saline.
New studies may clarify the risks associated with antibiotic combinations that include vancomycin, a drug with well-known nephrotoxicities.
Study of sugarcane workers in Nicaragua may help to explain a high prevalence of chronic kidney disease in Central America.
These factors include a history of heart failure, which was associated with 3-fold increased odds of acute kidney injury.
A uric acid level above 9.4 mg/dL at admission is associated with 79% increased odds of AKI compared with a level of 5.8-7.6 mg/dL.
It is associated with a lower risk of adverse renal outcomes compared with midazolam.
Risk factors include longer duration of AKI and hospitalization for congestive heart failure, acute coronary syndrome, and decompensated advanced liver disease.
Remarkably, 40% of men report an increase in use of performance-enhancing supplements; 29% are also concerned about their use.
Acute kidney injury is associated with a significant 22% increased odds of subsequence development of a blood pressure higher than 140/90 mm Hg.
In a study, 86% of patients who survived experienced renal recovery within 1 year.
Study findings show that contrast dosing is only a minor contributor to the overall burden of AKI.
In a study, the incidence of hyperphosphatemia, ionized hypocalcemia, and ionized hypercalcemia was 44%, 22%, and 23%, respectively.
Findings among patients at high risk of acute kidney injury, undergoing cardiac surgery
AKI developed in bodybuilders who injected anabolic steroids and ingested commercial protein and creatine products.
Older users of proton pump inhibitors had a 2-fold increased risk of AKI compared with non-users.
Investigators propose a protocol for when patients should be referred to nephrologists.
Recent meta-analysis compared continuous renal replacement therapy and extended daily dialysis.
Excessive consumption of iced tea has been linked to renal failure caused by oxalate nephropathy in a case study appearing in the New England Journal of Medicine.
Observational studies strongly support a correlation between synthetic marijuana and kidney damage.
Absence of association observed in patients with normal or near-normal baseline estimated glomerular filtration rate.
Mission 0by25 hopes to stop preventable deaths from AKI by 2025.
For reasons that are unclear, certain organs even performed better 6 months after transplant
The higher the dose of vancomycin, the greater the risk, researchers found.
A substantial minority of surviving patients also developed long-term dependence on dialysis.
In this Australian study, nearly 15% of hip- or knee-replacement patients experienced acute kidney injury--far higher than previously thought.
Acute kidney injury developed in 23% of renal cell carcinoma patients receiving everolimus.
For patients at high risk of cardiovascular disease, resting heart rate predicts renal outcomes singly and in combination.
Aspirin and clonidine increased the risk of major bleeding and clinically important hypotension in acute kidney injury (AKI).
Renal and Urology News Articles
- Aggressive Therapy Warranted for Gleason 10 Prostate Cancer
- PET/CT May Improve Imaging of Recurrent Prostate Cancer
- Adding MRI Does Not Boost Prostate Cancer Upgrading Rate
- Both High and Low Uric Acid Levels Tied to Higher Mortality
- Trulicity Labeling Updated to Include Data on T2D Patients With CKD
Sign Up for Free e-newsletters
NEPHROLOGY & UROLOGY NEWS
- Acute Kidney Injury (AKI)
- Chronic Kidney Disease (CKD)
- Contrast Nephropathy
- Cardiovascular Disease (CVD)
- Diabetic Nephropathy
- End-stage Renal Disease (ESRD)
- Lupus Nephritis
- Peritoneal Dialysis
- Secondary Hyperparathyroidism (SHPT)