Acute Kidney Injury News Archive

Acute Kidney Injury Follow-up Falls Short

Acute Kidney Injury Follow-up Falls Short

Three-quarters of patients hospitalized with acute kidney injury in Alberta, Canada did not visit a kidney specialist within 12 months of discharge.

Urinary Biomarker May Predict AKI After Heart Surgery

Urinary Biomarker May Predict AKI After Heart Surgery

Elevated levels of the two proteins can predict risk of acute kidney injury.

Vancomycin, Piperacillin/Tazobactam Combo Ups AKI in Kids

Vancomycin, Piperacillin/Tazobactam Combo Ups AKI in Kids

Risk of AKI in hospitalized children higher than with IV vancomycin, other antipseudomonal -lactam

AKI After Computed Tomography Not Tied to Contrast

AKI After Computed Tomography Not Tied to Contrast

AKI occurred with similar frequency among patients who did and did not receive contrast medium.

AKI Risks Not Up With SGLT2 Inhibitors

AKI Risks Not Up With SGLT2 Inhibitors

Findings do not suggest an increased risk of AKI associated with SGLT2 inhibitor use in patients with type 2 diabetes.

Mortality Up for ER Patients Discharged With AKI

Mortality Up for ER Patients Discharged With AKI

Higher mortality was seen in association with an emergency department discharge with acute kidney injury vs no acute kidney injury.

Post-PCI Acute Kidney Injury Not Linked to Contrast Use

Post-PCI Acute Kidney Injury Not Linked to Contrast Use

Myocardial infarction patients who underwent percutaneous coronary intervention had an AKI rate similar to those who did not have the procedure.

AKI Predictors in PE Patients Identified

AKI Predictors in PE Patients Identified

Chronic kidney disease and anemia are associated with an increased risk for acute kidney injury in patients with pulmonary embolism.

Children With Diabetic Ketoacidosis at High Risk of AKI

Children With Diabetic Ketoacidosis at High Risk of AKI

Of the children who developed acute kidney injury, 34.9% had stage 1, 45.3% had stage 2, and 19.8% had stage 3.

Marathon Runners May Develop AKI, Tubular Injury

Marathon Runners May Develop AKI, Tubular Injury

An increase in injury and repair biomarker levels suggests structural damage to renal tubules occurring after marathon.

Chronic Kidney Disease More Likely in PPI Users

Chronic Kidney Disease More Likely in PPI Users

Proton pump inhibitors need not first cause acute kidney injury for CKD risk to be elevated.

Furosemide With Matched Hydration Prevents Contrast Nephropathy

Furosemide With Matched Hydration Prevents Contrast Nephropathy

Compared with control treatment, RenalGuard therapy correlated with significantly reduced CI-AKI, as well as a reduced need for renal replacement therapy.

Kidney Function Predicts Hospital Discharge, Mortality After Stroke

Kidney Function Predicts Hospital Discharge, Mortality After Stroke

Patients with an eGFR below 60 mL/min/1.73 m2 were more likely to die in the hospital or be discharged to hospice.

Platelet Counts Linked to AKI Severity in Pediatric Open-Heart Surgery

Platelet Counts Linked to AKI Severity in Pediatric Open-Heart Surgery

There is a strong association between magnified nadir platelet counts and the severity of AKI.

Previous AKI Episode Associated With Pregnancy Risks

Previous AKI Episode Associated With Pregnancy Risks

Women with r-AKI had increased rates of preeclampsia and premature infant births, compared with controls.

AKI Is a Risk Factor for Delirium, Coma in Critically Ill

AKI Is a Risk Factor for Delirium, Coma in Critically Ill

The researchers found that stage 2 acute kidney injury was associated with increased risk of delirium and coma as was stage 3 acute kidney injury.

Severe AKI in Young ICU Patients Predicts Higher Mortality

Severe AKI in Young ICU Patients Predicts Higher Mortality

The condition also is associated with greater use of renal-replacement therapy and mechanical ventilation.

Early RRT for AKI May Lower Risk of Dialysis Dependence

Early RRT for AKI May Lower Risk of Dialysis Dependence

It also may shorten intensive care unit and hospital length of stay versus late RRT in critically ill patients, meta-analysis reveals.

Higher Uric Acid Levels in Critically Ill Patients Up AKI Risk

Higher Uric Acid Levels in Critically Ill Patients Up AKI Risk

Odds of acute kidney injury increases by 29% with each 1 mg/dL increment in uric acid level at ICU admission.

Factors Linked to Worse Post-Surgical Kidney Function ID'd

Factors Linked to Worse Post-Surgical Kidney Function ID'd

Factors including low preoperative mean arterial BP tied to increases in eGFR, kidney injury.

Genetic Loci Linked to Acute Kidney Injury

Genetic Loci Linked to Acute Kidney Injury

Four single-nucleotide polymorphisms at two loci identified in discovery, replication populations.

Hyperphosphatemia Linked With Mortality in Septic AKI

Hyperphosphatemia Linked With Mortality in Septic AKI

Hyperphosphatemia was associated with more than double the risk of death from any cause.

Better AKI Patient Survival Linked to Negative Fluid Balance

Better AKI Patient Survival Linked to Negative Fluid Balance

The mortality rate among patients with negative fluid balance was just 7.4%, compared with 43.5% for patients with a positive fluid balance.

Acute Kidney Injury Progression Predicted by Urinary Biomarkers

Acute Kidney Injury Progression Predicted by Urinary Biomarkers

Study identifies 3 biomarkers that could detect increasing risk of worsening AKI in patients with acute cardiorenal syndrome.

More Intensive Renal Replacement Therapy Possibly Harmful

More Intensive Renal Replacement Therapy Possibly Harmful

This approach is associated with lower urine output during the first 7 days of therapy.

Drug Combinations May Increase Acute Kidney Injury Risk

Drug Combinations May Increase Acute Kidney Injury Risk

NSAIDs + diuretics with or without additional renin-angiotensin aldosterone agents demonstrated the strongest level of evidence.

Acute Kidney Injury May Up Long-Term Risk of Cardiovascular Mortality

Acute Kidney Injury May Up Long-Term Risk of Cardiovascular Mortality

In a meta-analysis, AKI was associated with an 86% increased risk of CV-related death and 38% increased risk of other major CV events.

FDA Strengthens AKI Warning for Some SGLT2 Inhibitors

FDA Strengthens AKI Warning for Some SGLT2 Inhibitors

The Food and Drug Administration (FDA) announced it is strengthening the current warning about the risk of acute kidney injury for drug products containing canagliflozin (Invokana, Invokamet) and dapagliflozin (Farxiga, Xigduo XR).

CKD Progression After Acute Kidney Injury Characterized

CKD Progression After Acute Kidney Injury Characterized

Male gender, diabetes, and renal function decline at 90 days implicated as risk factors; patients rarely progress to end-stage renal disease.

Fluid Overload at RRT Initiation Ups AKI Patients' Long-Term Mortality

Fluid Overload at RRT Initiation Ups AKI Patients' Long-Term Mortality

Japanese study demonstrates a 2-fold increased risk of death from any cause.

Risk Factors ID'd for Early Mortality After Starting CRRT

Risk Factors ID'd for Early Mortality After Starting CRRT

High FiO2 and norepinephrine in AKI patients increases their risk of death within 24 hours of being placed on continuous renal replacement therapy.

Critically Ill Acute Kidney Injury Patients Benefit From Early RRT

Critically Ill Acute Kidney Injury Patients Benefit From Early RRT

Study demonstrates improved 90-day survival and greater likelihood of recovering renal function.

In-Hospital Mortality From Dialysis-Requiring AKI Declining

In-Hospital Mortality From Dialysis-Requiring AKI Declining

Patients were 40% less likely to die in 2011 compared with 2001, study finds.

No Survival Advantage With Early Renal-Replacement Therapy in AKI

No Survival Advantage With Early Renal-Replacement Therapy in AKI

Mortality no different for early versus delayed strategy for patients with severe acute kidney injury.

AKI After RCC Surgery On the Rise

AKI After RCC Surgery On the Rise

Nearly 6% of patients who underwent partial or radical nephrectomy between 1998 and 2010 developed AKI.

Hospital- vs Community-Acquired AKI

Hospital- vs Community-Acquired AKI

Poor long-term outcomes found even in patients with community-acquired AKI but not hospitalized.

No Benefit, Kidney Risk Found for Perioperative Statins

No Benefit, Kidney Risk Found for Perioperative Statins

Statins don't prevent complications and may cause acute kidney injury, researchers report.

ACEI/ARBs Improve AMI Outcomes Regardless of Kidney Function

ACEI/ARBs Improve AMI Outcomes Regardless of Kidney Function

Treatment linked to improved long-term survival, regardless of underlying kidney function.

CMX-2043 Did Not Reduce Contrast-Induced Nephropathy

CMX-2043 Did Not Reduce Contrast-Induced Nephropathy

CARIN trial reported no significant differences in acute kidney injury incidence between novel compound CMX-2043 and placebo.

Aliskiren/Enalapril Combo Results in More Harms in Heart Failure

Aliskiren/Enalapril Combo Results in More Harms in Heart Failure

The addition of aliskiren to enalapril led to more adverse events in patients with chronic heart failure without an increase in benefit.

ACE Inhibitors, ARBs Comparable for Diabetic Retinopathy Patients

ACE Inhibitors, ARBs Comparable for Diabetic Retinopathy Patients

Study finds no significant difference in the rates of all-cause mortality, major cardiac events, and hospital admission with hyperkalemia or AKI.

World Kidney Day 2016 Focuses on Disease in Childhood

World Kidney Day 2016 Focuses on Disease in Childhood

10% of the population worldwide is impacted by some form of kidney damage.

Peri-Op Statin Therapy Does Not Prevent AKI After Cardiac Surgery

Peri-Op Statin Therapy Does Not Prevent AKI After Cardiac Surgery

The trial was stopped for futility after 615 patients completed the study.

AKI After Cardiac Surgery Linked to Worse Survival, Renal Outcomes

AKI After Cardiac Surgery Linked to Worse Survival, Renal Outcomes

Acute kidney injury increased the likelihood of advanced chronic kidney disease in elderly patients.

Statin Use May Raise Kidney Disease Risk

Statin Use May Raise Kidney Disease Risk

Statin users had 30% increased odds of acute kidney injury and 36% increased odds of chronic kidney disease compared with non-users.

IV Iron Safe for Treating Anemia in Acute Kidney Injury Patients

IV Iron Safe for Treating Anemia in Acute Kidney Injury Patients

In a case-control study, the treatment did not adversely affect mortality or recovery from AKI.

AKI Diagnostic Testing May Be Excessive

AKI Diagnostic Testing May Be Excessive

Results of some urine and blood tests are unlikely to affect diagnosis or management of acute kidney injury.

CKD Risk Following Inpatient Acute Kidney Injury Characterized

CKD Risk Following Inpatient Acute Kidney Injury Characterized

Even mild AKI with rapid recovery is associated with increased risk of chronic kidney disease stage 3 or higher.

Long-Term Cardiovascular Mortality Linked to Post-Op AKI, CKD

Long-Term Cardiovascular Mortality Linked to Post-Op AKI, CKD

Even surgery patients with stage 1 AKI without true organ damage had a 43% increase in cardiovascular mortality risk within 10 years compared with patients with no kidney disease.

CKD Progression to Stage 4 Predicts Increased Death Risk

CKD Progression to Stage 4 Predicts Increased Death Risk

CKD progression from stage 3 to stage 4 also was associated with increased risks of acute kidney injury and hospitalization.

Renal Biomarkers Predict Diabetes Outcomes

Renal Biomarkers Predict Diabetes Outcomes

AKI, albuminuria, eGFR considered separately or together can predict adverse outcomes in diabetes.

Tenofovir-Linked Acute Kidney Injury Common in HIV

Tenofovir-Linked Acute Kidney Injury Common in HIV

Fewer than half of patients with TFD-linked AKI had renal function recovery after drug withdrawal.

Acute Kidney Injury More Likely in African Americans

Acute Kidney Injury More Likely in African Americans

Increased risk observed in the VA health system unlikely to be fully explained by disparities in access to care.

Acute Kidney Injury Raises Heart Failure Risk

Acute Kidney Injury Raises Heart Failure Risk

AKI is independently associated with a 27% increased risk of heart failure, according to a study of hospitalized U.S. veterans.

Acute Kidney Injury Risk Relatively Low After GI Surgery

Acute Kidney Injury Risk Relatively Low After GI Surgery

AKI developed in 2.1% of operations and was more common after major, open, and acute surgeries.

Buffered Crystalloid Solution Doesn't Cut AKI Risk

Buffered Crystalloid Solution Doesn't Cut AKI Risk

Risk of developing acute kidney injury similar with buffered crystalloid, saline.

Adding Beta-Lactams to Vancomycin Raises AKI Risk

Adding Beta-Lactams to Vancomycin Raises AKI Risk

New studies may clarify the risks associated with antibiotic combinations that include vancomycin, a drug with well-known nephrotoxicities.

Researchers Zero In on Cause of 'Mesoamerican Nephropathy'

Researchers Zero In on Cause of 'Mesoamerican Nephropathy'

Study of sugarcane workers in Nicaragua may help to explain a high prevalence of chronic kidney disease in Central America.

Risk Factors for Aminoglycoside-Induced AKI Identified

Risk Factors for Aminoglycoside-Induced AKI Identified

These factors include a history of heart failure, which was associated with 3-fold increased odds of acute kidney injury.

High Uric Acid at Hospital Admission Raises Acute Kidney Injury Risk

High Uric Acid at Hospital Admission Raises Acute Kidney Injury Risk

A uric acid level above 9.4 mg/dL at admission is associated with 79% increased odds of AKI compared with a level of 5.8-7.6 mg/dL.

AKI Risk Lower with Propofol for ICU Sedation

AKI Risk Lower with Propofol for ICU Sedation

It is associated with a lower risk of adverse renal outcomes compared with midazolam.

Predictors of Recurrent Acute Kidney Injury Identified

Predictors of Recurrent Acute Kidney Injury Identified

Risk factors include longer duration of AKI and hospitalization for congestive heart failure, acute coronary syndrome, and decompensated advanced liver disease.

Men Increasingly Using Legal Performance-Enhancing Drugs

Men Increasingly Using Legal Performance-Enhancing Drugs

Remarkably, 40% of men report an increase in use of performance-enhancing supplements; 29% are also concerned about their use.

AKI Is a Risk Factor for Elevated BP

AKI Is a Risk Factor for Elevated BP

Acute kidney injury is associated with a signi­ficant 22% increased odds of subsequence development of a blood pressure higher than 140/90 mm Hg.

Renal Replacement Need After Cardiac Surgery Hikes Death Risk

Renal Replacement Need After Cardiac Surgery Hikes Death Risk

In a study, 86% of patients who survived experienced renal recovery within 1 year.

Acute Kidney Injury Implicated in Nearly One-Third of Post-PCI Deaths

Acute Kidney Injury Implicated in Nearly One-Third of Post-PCI Deaths

Study findings show that contrast dosing is only a minor contributor to the overall burden of AKI.

Adverse Events Common During Continuous Renal Replacement Therapy

Adverse Events Common During Continuous Renal Replacement Therapy

In a study, the incidence of hyperphosphatemia, ionized hypocalcemia, and ionized hypercalcemia was 44%, 22%, and 23%, respectively.

Remote Ischemic Preconditioning Reduces Surgery-related AKI

Remote Ischemic Preconditioning Reduces Surgery-related AKI

Findings among patients at high risk of acute kidney injury, undergoing cardiac surgery

Acute Kidney Injury Linked to Anabolic Steroids, Supplements

Acute Kidney Injury Linked to Anabolic Steroids, Supplements

AKI developed in bodybuilders who injected anabolic steroids and ingested commercial protein and creatine products.

Acute Kidney Injury Linked to PPIs

Acute Kidney Injury Linked to PPIs

Older users of proton pump inhibitors had a 2-fold increased risk of AKI compared with non-users.

ICU Patients on RRT Rarely Have Nephrology Follow-up

ICU Patients on RRT Rarely Have Nephrology Follow-up

Investigators propose a protocol for when patients should be referred to nephrologists.

Dialysis Modalities Show Similar Outcomes in AKI

Dialysis Modalities Show Similar Outcomes in AKI

Recent meta-analysis compared continuous renal replacement therapy and extended daily dialysis.

Tea Overconsumption Causes Nephropathy

Tea Overconsumption Causes Nephropathy

Excessive consumption of iced tea has been linked to renal failure caused by oxalate nephropathy in a case study appearing in the New England Journal of Medicine.

Synthetic Marijuana Linked to Acute Kidney Injury

Synthetic Marijuana Linked to Acute Kidney Injury

Observational studies strongly support a correlation between synthetic marijuana and kidney damage.

Dialysis for AKI Does Not Hike Risk of Major Cardiovascular Events

Dialysis for AKI Does Not Hike Risk of Major Cardiovascular Events

Absence of association observed in patients with normal or near-normal baseline estimated glomerular filtration rate.

Commission Seeks to End AKI Deaths by 2025

Commission Seeks to End AKI Deaths by 2025

Mission 0by25 hopes to stop preventable deaths from AKI by 2025.

Some Injured Kidneys Suitable for Transplant

Some Injured Kidneys Suitable for Transplant

For reasons that are unclear, certain organs even performed better 6 months after transplant

Vancomycin May Cause Kidney Damage in Children

Vancomycin May Cause Kidney Damage in Children

The higher the dose of vancomycin, the greater the risk, researchers found.

Dialysis-Requiring AKI Quadrupled in ICU Patients

Dialysis-Requiring AKI Quadrupled in ICU Patients

A substantial minority of surviving patients also developed long-term dependence on dialysis.

Higher AKI Rates Suspected After Joint Surgery

Higher AKI Rates Suspected After Joint Surgery

In this Australian study, nearly 15% of hip- or knee-replacement patients experienced acute kidney injury--far higher than previously thought.

Everolimus Raises AKI Risk in Some Cancer Patients

Everolimus Raises AKI Risk in Some Cancer Patients

Acute kidney injury developed in 23% of renal cell carcinoma patients receiving everolimus.

Resting Heart Rate Predicts Renal End Points in Pre-CVD Patients

Resting Heart Rate Predicts Renal End Points in Pre-CVD Patients

For patients at high risk of cardiovascular disease, resting heart rate predicts renal outcomes singly and in combination.

Post-Op Acute Kidney Injury Not Prevented by Aspirin, Clonidine

Post-Op Acute Kidney Injury Not Prevented by Aspirin, Clonidine

Aspirin and clonidine increased the risk of major bleeding and clinically important hypotension in acute kidney injury (AKI).

Anemia Found to Affect Renal Recovery from Acute Kidney Injury (AKI)

Anemia Found to Affect Renal Recovery from Acute Kidney Injury (AKI)

Highest quintile of hemoglobin associated with 6-fold increased odds of complete or partial recovery of anemia in acute kidney injury (AKI).

Hospital-Acquired Acute Kidney Injury (AKI) Ups Early Readmission Risk

Hospital-Acquired Acute Kidney Injury (AKI) Ups Early Readmission Risk

Researchers observe a significant 21% increased odds of rehospitalization for acute kidney injury (AKI) within 30 days.

Pre-Treatment Statins Reduce Acute Kidney Injury (AKI) Risk

Pre-Treatment Statins Reduce Acute Kidney Injury (AKI) Risk

Review shows reduction in acute kidney injury with high-dose statins versus low-dose or placebo.

Possible Tissue Injury Predictor in Transplant Recipients Found

Possible Tissue Injury Predictor in Transplant Recipients Found

Researchers may have found a predictor for focal segmental glomerulosclerosis (FSGS) in kidney transplant recipients.

Many Kidney Failure Patients Unaware of Transplant Benefits

Many Kidney Failure Patients Unaware of Transplant Benefits

The vast majority of kidney failure patients reported that they were doing fine on dialysis and did not see a need for a kidney transplant.

Acute Kidney Injury (AKI) Common in Intensive Care Units

Acute Kidney Injury (AKI) Common in Intensive Care Units

Acute kidney injury is common in critically ill surgical patients and is associated with worse survival.

Acute Kidney Injury Not Increased By Oral Sodium Phosphate

Acute Kidney Injury Not Increased By Oral Sodium Phosphate

No increased risk of acute kidney injury with pre-colonoscopy sodium phosphate versus polyethylene glycol.

Acute Renal Dysfunction Linked to Sugarcane Harvesting

Acute Renal Dysfunction Linked to Sugarcane Harvesting

The association stems from performing prolonged, physically overwhelming work in an unhealthy environment.

Chronic Kidney Disease (CKD) Predicts Acute Kidney Injury (AKI) After Renal Cell Carcinoma Surgery

Chronic Kidney Disease (CKD) Predicts Acute Kidney Injury (AKI) After Renal Cell Carcinoma Surgery

Other predictors include neurovascular disease, obesity, and surgical approach.

FDA Clears Lab Test for Predicting Acute Kidney Injury (AKI)

FDA Clears Lab Test for Predicting Acute Kidney Injury (AKI)

NephroCheck detects substances in the urine that are associated with acute kidney injury (AKI).

Causes of Acute Interstitial Nephritis (AIN) Differ in the Elderly

Causes of Acute Interstitial Nephritis (AIN) Differ in the Elderly

Individuals aged 65 and older are more likely than younger people to develop AIN as a result of medication use.

Acute Kidney Injury Linked to Atypical Antipsychotic Drugs

Acute Kidney Injury Linked to Atypical Antipsychotic Drugs

Seniors taking atypical antipsychotic drugs are at higher risk of acute kidney injury.

Interventions Prevent Contrast-Induced Acute Kidney Injury

Interventions Prevent Contrast-Induced Acute Kidney Injury

Quality improvements protect patients undergoing percutaneous coronary intervention.

Advanced Kidney Disease (CKD) Linked to Worse Post-Bypass Outcomes

Advanced Kidney Disease (CKD) Linked to Worse Post-Bypass Outcomes

Severe CKD raised the risk of in-hospital death after coronary artery bypass grafting surgery.

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