Tenofovir-Linked Acute Kidney Injury Common in HIV

Fewer than half of patients with TFD-linked AKI had renal function recovery after drug withdrawal.
Fewer than half of patients with TFD-linked AKI had renal function recovery after drug withdrawal.

(HealthDay News) -- Acute kidney injury (AKI) associated with tenofovir disoproxil fumarate (TFD) is prevalent in HIV-infected patients, according to a study presented at the American Society of Nephrology's Kidney Week 2015, held from Nov. 3 to 8 in San Diego.

Teg Marcos Veiga, MD, from the University Federal de Pernambuco in Recife, Brazil, and colleagues describe the clinical characteristics and outcomes of AKI associated with TFD in a retrospective cohort. Seventy-two patients were assessed during the study period.

The researchers identified nephrotoxic AKI in 36 cases, of which 52% correlated with TFD (19 patients). In all cases the drug was withdrawn. TFD nephrotoxicity without other associated factors was seen in seven patients. Eight of the 19 patients (42%) with TFD-linked AKI had renal function recovery. Almost 37% of patients required hemodialysis. Four of the patients died, three due to sepsis and one due to hemorrhagic shock.

"Since tenofovir is a first-line therapy for HIV, infectious disease specialists and clinicians should be aware of the risk of nephrotoxicity related to its use, especially in the context of other drugs and factors that could increase AKI," Veiga said in a statement.

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