Generic Name and Formulations:
Zafirlukast 10mg, 20mg; tabs.
Indications for ACCOLATE:
Prophylaxis and chronic treatment of asthma.
Take 1hr before or 2hrs after meals. 20mg twice daily.
Take 1hr before or 2hrs after meals. <5yrs: not recommended. 5–11yrs: 10mg twice daily.
Not for primary treatment of acute attack. Discontinue if clinical symptoms of liver dysfunction occur; do not resume if confirmed by lab results. Caution when withdrawing from oral steroids. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended.
Leukotriene receptor antagonist.
Potentiates warfarin (monitor PT and adjust warfarin dose). Caution with drugs metabolized by CYP2C9 (eg, tolbutamide, phenytoin, carbamazepine) or CYP3A4 (eg, dihydropyridine calcium channel blockers, cyclosporine, cisapride). Zafirlukast plasma levels reduced by erythromycin, theophylline. Zafirlukast plasma levels increased by aspirin. May increase theophylline levels.
Headache, infection, GI upset, pain, fever; neuropsychiatric events (eg, insomnia, depression); rarely, hepatic dysfunction (esp. in females), agranulocytosis.
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